Welcome to your Personalized Medicine

 

The main objectives of "personalized medicine.in" are

 

✓Developing a reliable educational platform for both scientific and non-scientific community. 

✓Assisting researchers to discuss with people of similar interests and to facilitate networking.

✓To develop or aiding in the development of easy to implement tools for personalizing treatment.

✓Curating and providing authentic information on existing strategies and tools.

✓Implementing personalized dose calculators free to access for registered medical practitioners.

 

PHARMCOGENETICS/OMICS

Enabling predictive, preventive, precision and personalized medicine

Every individual is different from another and hence should be considered as a different entity. As many variations are there in the universe, all are seen in human beings”. – Charaka Samhita
It's far more important to know what person has the disease than what disease the person has” – Hippocrates

Clinical practice is being evolved during decades to improve the standards of patient care, diagnosis, and treatment. Evolution of medical practice from empirical treatment to evidence based medicine happened with the development of newer techniques and tools foraccurate diagnosis and practice. However, treatment options for many ailments were developed based on trials conducted in non-homogeneous numbers distinctly many times less than the population receiving medication after approval. During past years,we also witnessed awareness about pharmacovigilance and many medications were withdrawn after being associated with rare fatal conditions, which might occur in few tens and hundreds of patients among thousand and millions receiving the medication. This procedure of drug development (clinical) has always been a trial and error method to evaluate the benefits and risks; and due to the involvement of lots of investments, there is always peer pressure for the marketing of medication. Reasons for most of these rare events, and basis for the occurrence of these events in only a few patients, but not in all, have always been a problem to be investigated and were attributed to idiosyncrasy. The concept of medication i.e. “One fits for all” is in transformation towards theconcept of “One fits One or Few” only.
There is a concept described inancient literature and earlier dictums about differences in the response to a drug by different ethnicities, and races across the globe. In ancient Greece, Pythagoras described how fava beans could be poisonous to certain individuals, causing hemolytic anemia. The basis for this favism has been attributed to the mutations in glucose-6-phosphate dehydrogenase encoding. At the beginning of 19th century, Archibald Garrod hypothesized and demonstrated that alkaptonuria is not a disease but the result of an alternative course of metabolism, caused by chemical individuality and recurring in interbred families, therefore suggesting a genetic basis for the condition.Similar descriptions were given in Ayurveda which originated 5000 years ago in India, wherein all individuals were classified into different 'Prakriti' types based on the theory of tridosha and each type had varying degree of predisposition to different diseases. The classification is independent of caste, race, and ethnic background and is in practice to administer different medication or amount of medication to individuals with similar ailment but belonging to different dosha (Vata, Pitta and Kapha). The reasons for this type of practice and different phenotypes is now attributed to different genetic makeup of an individual and chemical modifications of the genes in an individual in his life time.